Overweight young female donors have a lower post-donation re­serve capacity

M. van Londen, G.J Navis, M.H. de Borst, A.T. Lely

Chair(s): dr. Marion J. Siebelink, programmamanager Transplantatie Centrum, UMC Groningen & dr. Raechel J. Toorop, transplantatiechirurg, UMC Utrecht

Thursday 10 march 2016

9:10 - 9:20h at Zaal 14

Categories: Parallelsessie (donatie)

Parallel session: Parallelsessie IX - Donatie en Allocatie

Recent work shows that young female kidney donors are at increased risk of developing gestational hypertension or preeclampsia. Absence of pregnancy-induced renal vasodilation is a hallmark of preeclampsia. We previously found that renal reserve capacity (RC) is reduced after donation in donors with high BMI, and older donors, but data in female donors of childbearing age are sparse so far. We investigated RC in 58 female donors of childbearing age (25) were more likely to have a RC loss of >5 ml/min (p=0.04) and BMI was inversely associated with the RC after transplantation (st. beta -0.35, p=0.02). We also observed a non-significant association of BMI with the development proteinuria (st. beta 0.25, p=0.06) at 2 months after transplantation. These data show that overweight is associated with lower post-donation reserve capacity in young female donors. We postulate that reduced renal reserve capacity can explain the increased risk of preeclampsia and gestational hypertension in overweight female kidney donors. Obesity is a well-established risk factor for preeclampsia and we propose that female kidney donors with the desire to have children especially, should be counselled to adopt a healthy lifestyle with a healthy body weight.